TIDES Asia
Meet us at TIDES Asia, Grand Nikko Tokyo Daiba, Tokyo, Japan
Booth# 24
Presentations:
24 Feb. 7:10 amStrategies for Manufacturing of Long and Complex Peptides: Technical Considerations and Case StudiesThe synthesis of long and structurally complex peptides presents significant manufacturing challenges, including low yields, side reactions and aggregation. This presentation explores customized strategies to overcome these hurdles, emphasizing hybrid synthesis techniques that integrate solid-phase and solution-phase methods to improve both efficiency and scalability. Key technical aspects are addressed, such as sourcing specialized raw materials, managing coupling inefficiencies, and incorporating complex moieties like PEG spacers and fatty acids. Special attention is given to process design considerations aligned with green chemistry principles, focusing on solvent minimization. Real case studies will demonstrate the successful application of these approaches, offering actionable insights for the development and industrialization of complex peptide therapeutics. El Djouhar Rekai, PhD, Head of Process & Analytical Development and Robert Hagopian, Global Director, Director, Biotech Partnerships/Key Opinion Leader |
26 Feb. 11:00amPolyPeptide Key Technology Enablers to Speed Up IND and Early Clinical TrialsPreclinical development and IND milestones are often measured by speed to market, supported by toxicology evaluation, first-in-human studies, and seamless scalability. As a global leader in peptide CDMO services, PolyPeptide combines speed, flexibility, deep process knowledge, and strong process economy and control. We leverage advanced process intensification technologies such as flow chemistry, automation, PAT, and high-capacity resins to deliver sufficient API rapidly and reliably. This presentation will share results achieved with these enablers and explain why partnering with PolyPeptide is a game changer for tox and early-phase peptide manufacturing. Fabien Rousset, PhD, Global Director Innovation
|
