Expanding the Reach of Sustainable Solid-Phase Peptide Synthesis
Expert views
Alloc protecting group expanded the peptide synthesis toolbox. Its removal can sometimes be seen as an issue: toxic solvents, air-sensitive Pd0) reagents, challenging upscaling. Not anymore
A new method eliminates metal catalysts and hazardous reagents. It uses iodine/water in PolarClean and EtOAc to enable:
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On-resin Alloc removal
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One-pot removal + coupling
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Full compatibility with Fmoc and Alloc amino acids
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Seamless use with long peptides (achieved with a 39 amino acid peptide)
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Successful upscaling to 10 g
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TFA-free cleavage
Cleaner. Simpler. Scalable.
An upgrade for sustainable peptide manufacturing.
See the article published in Organic Letters: Expanding the Reach of Sustainable Solid-Phase Peptide Synthesis: One-Pot, Metal-Free Alloc Removal–Peptide Coupling
Org. Lett. 2025, 27, 12, 2891–2896
https://doi.org/10.1021/acs.orglett.5c00423
Authors: Jan Pawlas and Andreas Lindgren
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