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Research article: Synthesis of Peptides by Reactive Extrusion. Application to the Continuous and Solventless Preparation of Aspartame.
25 Apr 2024 - The latest results from an innovative mechanochemical approach to continuous and solventless peptide synthesis. PolyPeptide is dedicated to applying relevant principles of green chemistry to mitigate […]
Read morePolyPeptide participates in industry effort to advance sustainability
26 Mar 2024 - Increasing manufacturing volume requirements and the high process mass intensity (PMI) of peptide synthesis warrants continued industry efforts for more sustainable production processes. PolyPeptide collaborated with […]
Read moreQuality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactions by TBEC/Oxyma Couplings in an Environmentally Sensible Solvent
23 Jun 2023 - Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactions by TBEC/Oxyma Couplings in an Environmentally […]
Read moreTrending topics at PolyPeptide
1 Jun 2023 - We are proud to share some of the recent recorded presentations from our experts at TIDES USA 2023: “Raw material control strategy” Eran Benjamin, Global Director […]
Read moreAssessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis
4 May 2023 - Jan Pawlas and Jon H. Rasmussen Abstract Diisopropylcarbodiimide (DIC) constitutes one of the most widely used coupling reagents for amide bond formation in peptide synthesis. […]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
4 Apr 2023 - Bryan, M. C.; Dalton, C.; Díaz-Rodríguez, A.; Doerfler, J.; Engl, O. D.; Molina, A. G.; Harawa, V.; Kelly, C. B.; Li, W.; Munday, R. H.; Pawlas, […]
Read moreDeveloping the Toolbox for Sustainable Peptide Manufacturing
24 Mar 2023 - The need for sustainable manufacturing practices is a major challenge for the worldwide industry, and the pharma world is increasingly engaged in this important green transformation. […]
Read moreOvercoming Oligonucleotide Manufacturing Challenges
24 Mar 2023 - The Oligonucleotide CMO industry faces a number of challenges – Demand out pacing capacity for manufacturing, available expertise, high solvent and waste usage to name a […]
Read moreChemical strategies in extending half-lives of therapeutic peptides
24 Mar 2023 - Therapeutic peptides have been proven to be very effective in treating critical human diseases. Their number on the pharmaceutical market has significantly increased over the past […]
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