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Downstream Processes for peptide manufacturing: Optimization strategy and latest technical trends
2 Apr 2021 - This article highlights the key steps in the development and implementation of a proper purification strategy for the manufacture of peptide APIs. Our ambition is to recommend a structured methodology, including a good understanding of the separation mechanism to develop the process and to apply the latest technologies for the optimization of the purification step to reach the best performance of the manufacturing process. […]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
11 Mar 2021 - Dalton, C.; Diorazio, L. J.; Doerfler, J.; Engl, O. D.; Han, Z. S.; Howell, G. P.; Latham, J.; Li, W.; McLaws, M.; Munday, R. H.; Navarro, […]
Read moreMinimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
15 Jun 2020 - Aiming at advancing protocols for safer, environmentally sensible peptide synthesis we report our findings with regard to the occurrence of hydrogen cyanide (HCN, prussic acid) in amide bond-forming reactions mediated by diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma).[…]
Read moreMinimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
16 Mar 2020 - Webinar Abstract: Diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma) are the most widely used coupling reagents in peptide synthesis. McFarland et al. recently discovered the reaction between DIC and Oxyma, which forms hydrogen cyanide (HCN), […]
Read moreSelection of publications on significant advances in production and use of Peptides
1 Mar 2020 - We would like to share a selection of 10 publications reporting significant advances concerning production and use of Peptides, by Jan Pawlas, Ph.D. Scientist, Global Development, […]
Read moreSustainable, cost-efficient manufacturing of therapeutic peptides using chemo-enzymatic peptide synthesis (CEPS)
22 Nov 2019 - Using a large scale biocatalytic manufacture of the antidiabetic exenatide as an example, we report that chemo-enzymatic peptide synthesis (CEPS) constitutes an efficient method for sustainable manufacturing of therapeutic peptides. […]
Read moreQA interview: Focus innovation
21 Oct 2019 - Interview with Olivier Ludemann-Hombourger, Ph.D. Global Director Innovation & Technology of PolyPeptide Group […]
Read moreReGreen SPPS: enabling circular chemistry in environmentally sensible solid-phase peptide synthesis
15 Oct 2019 - Aiming at greener, scalable methods for cost-efficient peptide synthesis a solid-phase peptide synthesis (SPPS) protocol adhering to the principles of circular chemistry[…]
Read moreEconomic and environmental factors affecting the sustainability of peptide therapeutic manufacturing
14 Sep 2019 - The outlook for peptide therapeutic drugs is bright. The range of medical indications is expanding and the rate at which peptide therapeutic drugs are being approved is increasing.[…]
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