Diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma) are the most widely used coupling reagents in peptide synthesis. McFarland et al. recently discovered the reaction between DIC and Oxyma, which forms hydrogen cyanide (HCN). Controlling the formation of toxic side products is crucial for advancing protocols for safer and environmentally sensible peptide synthesis. HCN is formed during amino acid activation but also during amide bond forming reactions mediated by DIC and Oxyma
Marion Erny, March 16, 2020
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