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Minimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
15 Jun 2020 - Aiming at advancing protocols for safer, environmentally sensible peptide synthesis we report our findings with regard to the occurrence of hydrogen cyanide (HCN, prussic acid) in amide bond-forming reactions mediated by diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma).[…]
Read moreMinimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
16 Mar 2020 - Webinar Abstract: Diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma) are the most widely used coupling reagents in peptide synthesis. McFarland et al. recently discovered the reaction between DIC and Oxyma, which forms hydrogen cyanide (HCN), […]
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