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Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis
4 May 2023 - Jan Pawlas and Jon H. Rasmussen Abstract Diisopropylcarbodiimide (DIC) constitutes one of the most widely used coupling reagents for amide bond formation in peptide synthesis. […]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
4 Apr 2023 - Bryan, M. C.; Dalton, C.; Díaz-Rodríguez, A.; Doerfler, J.; Engl, O. D.; Molina, A. G.; Harawa, V.; Kelly, C. B.; Li, W.; Munday, R. H.; Pawlas, […]
Read moreDeveloping the Toolbox for Sustainable Peptide Manufacturing
24 Mar 2023 - The need for sustainable manufacturing practices is a major challenge for the worldwide industry, and the pharma world is increasingly engaged in this important green transformation. […]
Read moreOvercoming Oligonucleotide Manufacturing Challenges
24 Mar 2023 - The Oligonucleotide CMO industry faces a number of challenges – Demand out pacing capacity for manufacturing, available expertise, high solvent and waste usage to name a […]
Read moreChemical strategies in extending half-lives of therapeutic peptides
24 Mar 2023 - Therapeutic peptides have been proven to be very effective in treating critical human diseases. Their number on the pharmaceutical market has significantly increased over the past […]
Read moreFrom 10 grams to several hundred – A case study in peptide GMP process development
17 Oct 2022 - Presentation from TIDES digital week, September 2022, by Niall McLoughlin, PhD, Development Project Chemist at PolyPeptide Group.[…]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
22 Sep 2022 - The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable (ACSGCI PR) promotes the use of green and sustainable chemistry in the pharma industry and beyond. As a part of this initiative, reviews covering Green Chemistry articles of interest from a pharmaceutical perspective are periodically disclosed.[…]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
13 Mar 2022 - Bryan, M. C.; Dalton, C.; Díaz-Rodríguez, A.; Doerfler, J.; Engl, O. D.; Ferguson, P.; Molina, A. G.; Han, Z. S.; Hosford, J.; Howell, G. P.; Hutchby, M.; Li, W.; Munday, R. H.; Navarro, A.; Parmentier, M.; Pawlas, J.; Richardson, P. F.; Smith III, W. J.; Steven, A.; Takale, B. S.; Terrett, J. A.; Treitler, D. S.; Zeng, M. Org. Process Res. Dev. 2022, 26, 2, 251–262Publication Date: February 2, 2022 […]
Read moreEnvironmentally Sensible Organocatalytic Fmoc/t Bu Solid-Phase Peptide Synthesis
28 Feb 2022 - We now report a proof-of-principle Fmoc/t-Bu SPPS in which both couplings and Fmoc deprotections were catalyzed by readily available reagents in an inexpensive green solvent. […]
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