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From 10 grams to several hundred – A case study in peptide GMP process development
17 Oct 2022 - Presentation from TIDES digital week, September 2022, by Niall McLoughlin, PhD, Development Project Chemist at PolyPeptide Group.[…]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
22 Sep 2022 - The American Chemical Society Green Chemistry Institute Pharmaceutical Roundtable (ACSGCI PR) promotes the use of green and sustainable chemistry in the pharma industry and beyond. As a part of this initiative, reviews covering Green Chemistry articles of interest from a pharmaceutical perspective are periodically disclosed.[…]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
13 Mar 2022 - Bryan, M. C.; Dalton, C.; Díaz-Rodríguez, A.; Doerfler, J.; Engl, O. D.; Ferguson, P.; Molina, A. G.; Han, Z. S.; Hosford, J.; Howell, G. P.; Hutchby, M.; Li, W.; Munday, R. H.; Navarro, A.; Parmentier, M.; Pawlas, J.; Richardson, P. F.; Smith III, W. J.; Steven, A.; Takale, B. S.; Terrett, J. A.; Treitler, D. S.; Zeng, M. Org. Process Res. Dev. 2022, 26, 2, 251–262Publication Date: February 2, 2022 […]
Read moreEnvironmentally Sensible Organocatalytic Fmoc/t Bu Solid-Phase Peptide Synthesis
28 Feb 2022 - We now report a proof-of-principle Fmoc/t-Bu SPPS in which both couplings and Fmoc deprotections were catalyzed by readily available reagents in an inexpensive green solvent. […]
Read moreSPPS: Process improvements to reduce solvent consumption
31 Jan 2022 - Introducing a new percolation wash concept for solid-phase peptide synthesis .[…]
Read moreCircular Aqueous Fmoc/t-Bu Solid-Phase Peptide Synthesis
16 Jul 2021 - Circular economy and aqueous synthesis are attractive concepts for sustainable chemistry. Here it is reported that the two can be combined in the universal method for peptide chemistry, fluorenylmethoxycarbonyl(Fmoc)/t-Bu solid-phase peptide synthesis (SPPS). […]
Read moreDownstream Processes for peptide manufacturing: Optimization strategy and latest technical trends
2 Apr 2021 - This article highlights the key steps in the development and implementation of a proper purification strategy for the manufacture of peptide APIs. Our ambition is to recommend a structured methodology, including a good understanding of the separation mechanism to develop the process and to apply the latest technologies for the optimization of the purification step to reach the best performance of the manufacturing process. […]
Read moreGreen Chemistry Articles of Interest to the Pharmaceutical Industry
11 Mar 2021 - Dalton, C.; Diorazio, L. J.; Doerfler, J.; Engl, O. D.; Han, Z. S.; Howell, G. P.; Latham, J.; Li, W.; McLaws, M.; Munday, R. H.; Navarro, […]
Read moreMinimizing HCN in DIC/Oxyma-Mediated Amide Bond-Forming Reactions
15 Jun 2020 - Aiming at advancing protocols for safer, environmentally sensible peptide synthesis we report our findings with regard to the occurrence of hydrogen cyanide (HCN, prussic acid) in amide bond-forming reactions mediated by diisopropylcarbodiimide (DIC) and ethyl (hydroxyimino)cyanoacetate (Oxyma).[…]
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