Chemical strategies in extending half-lives of therapeutic peptides

Therapeutic peptides have been proven to be very effective in treating critical human diseases. Their number on the pharmaceutical market has significantly increased over the past two decades. Thanks to the chemical modification strategies offering to significantly extend their half live and to overcome the biggest challenge of fast degradation in serum. This presentation gives examples of chemistry applied by the CDMOs and illustrate the evolving complexity of the therapeutic peptides to ensure a long-acting effect.

Presented at TIDES ASIA, March 7, 2023 by El Djouhar Rekaï, Head of Development & Manufacturing Process at PolyPeptide.