Despite numerous reports on catalytic amide bond formation (ABF), these methods have thus far had a minimal impact on the universal fluorenylmethoxycarbonyl (Fmoc)/t-Bu solid-phase peptide synthesis (SPPS) methodology. We now report a proof-of-principle Fmoc/t-Bu SPPS in which both couplings and Fmoc deprotections were catalyzed by readily available reagents in an inexpensive green solvent.
Pawlas, J.; Rasmussen, J. H. Environmentally Sensible Organocatalytic Fmoc/t Bu Solid-Phase Peptide Synthesis. Org. Lett. 2022, 24, 1827–1832.
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